How do statins work to lower cholesterol in the body?

How do statins work? 

Understanding how statins work will help you understand their possible adverse effects. Statins interfere with the production of cholesterol in the body, mainly in the liver. Since you synthesize your own cholesterol, it makes sense to limit the amount you consume if you are an overproducer. The liver together with cholesterol from food is responsible for most of the cholesterol found in the blood. There is a key step in cholesterol synthesis that these statins block quite effectively. The result is a reduction in blood LDLcholesterol levels of 25 percent to 45 percent, depending on the dose prescribed.

Since cholesterol is the key molecule for the production or synthesis of other essential compounds (like some hormones and bile acids needed for the digestion of fats) in the body, if the dose of the statin is too high there may be some adverse effects.

Statins and Cholesterol

Always remember: do as much as possible in terms of diet, not smoking, physical activity, and stress management so that if you still need a statin or any other cholesterol lowering drug a low dose will be effective.


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